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KMID : 1190620050010010006
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Journal of the Korean Wound Care Society
2005 Volume.1 No. 1 p.6 ~ p.14
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Preparation and Characterization of Polycaprolactone Nanofibrous Sheet for Wound Dressing Applications
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Oh Se-Heang
Cho Wan-Jin
Kim Hak-Yong
Lee Jin-Ho
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Abstract
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Electrospinning is a fabrication process that can produce nonwoven, highly porous nanometer-scale fiber-based matrices using an electrostatically driven jet of polymer solution or melt. The method represents an attractive approach for polymeric biomaterial processing which provides the morphology similar to extracellular matrix (ECM) that may retain mechanical strengths, flexibility, and high porosity. Recently, the nonwoven nanofibrous sheets have been considered as good wound dressing materials due to their high gas permeation and protection of wound from infection and dehydration. In this study, we fabricated polycaprolactone (PCL) nonwoven nanofibrous sheets and coated them with cell-adhesive protein, collagen type IV. The PCL nanofibrous sheets were characterized via morphology observation by a scanning electron microscope (SEM) and the measurement of mechanical properties by an universal testing machine (UTM). The cell compatibility of PCL nanofibrous sheets with/without collagen coating were investigated by in vitro cell culture using fibroblasts as a model cell. It was observed that the PCL nanofibrous sheets have a good cell compatibility as well as mechanical strengths and flexibility which can be applied for wound dressing applications. (J Korean Wound Care Soc 2005;1:6-14)
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KEYWORD
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Electrospinning, Polycaprolactone (PCL), Nonwoven nanofibrous sheet, Cell compatibility, Wound dressing
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